The Regional Museum of Natural History at Mysore, is a museum in India with exhibits on plants, animals and geology of the southern region of India.

The Regional Museum of Natural History at Mysore, was inaugurated on 20 May 1995. It was undertaken by the government of India, ministry of environment and forests. The museum is located on the banks of Karanji Lake, with the Chamundi Hills visible in the background. It is now a landmark in the city. The museum exhibits plants, animals and geology of the southern region of India. The galleries emphasize the conservation of nature and natural resources while depicting ecological interrelationship among plants and animals. Visually challenged students can feel the exhibits of animals on the premises. The museum provides an extracurricular activity for schools and promotes environmental awareness.